Pace bowlers Matt Fisher and Saqib Mahmood will make their Test debuts for England in Barbados, where England will bat first in the second match of the series after winning the toss.
Captain Joe Root made the decision on Wednesday despite the memory of a shaky start in Antigua last week, where England lost four early wickets on day one.
Fisher and Mahmood replace Craig Overton and Mark Wood.
Overton fell ill overnight, while Wood incurred an injured right below during the first Test.
West Indies kept an unchanged team from the draw in Antigua, keeping faith with several players who did little to impress.
But the home team can draw on some good recent memories at Kensington Oval, where they bowled England out for 77 in the first innings three years ago.
The teams are playing a three-Test series in the Caribbean.
Kraigg Brathwaite (captain), John Campbell, Shamarh Brooks, Nkrumah Bonner, Jermaine Blackwood, Jason Holder, Joshua da Silva (wicketkeeper), Alzarri Joseph, Kemar Roach, Veerasammy Permaul, Jayden Seales
Alex Lees, Zak Crawley, Joe Root (captain), Dan Lawrence, Ben Stokes, Jonny Bairstow, Ben Foakes (wicketkeeper), Chris Woakes, Jack Leach, Matt Fisher, Saqib Mahmood.